Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique
نویسندگان
چکیده
منابع مشابه
Evaluation of furosemide-loaded alginate microspheres prepared by ionotropic external gelation technique.
Alginate microspheres containing furosemide were prepared by the ionotropic external gelation technique using Ca2+, Al3+ and Ba2+ ions. The incorporation efficiency of the prepared microspheres ranged between 65% and 93%. The effect of sodium alginate concentration, cross-linking ions and drying conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristi...
متن کاملAlginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine.
The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers--gelatine discs, muc...
متن کاملPreparation of Microspheres of Diclofenac Sodium by Ionotropic Gelation Technique
Diclofenac sodium is a non-steroidal anti-inflammatory drug used in the treatment of arthritis. Treatment with NSAIDs is observed to have gastro intestinal side effects and the formulation of Diclofenac sodium using biodegradable and biocompatible polymer in the form of microspheres is expected to decrease GI side effects. In the present study, different microsphere formulations of Diclofenac S...
متن کاملFormulation and evaluation of captropril microspheres by ionic gelation technique
The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered on the fact that the drug is freely water soluble. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatme...
متن کاملAlginate microspheres prepared by internal gelation: development and effect on insulin stability.
Recombinant human insulin was encapsulated within alginate microspheres by the emulsification/internal gelation technique with the objective of preserving protein stability during encapsulation procedure. The influence of process and formulation parameters was evaluated on the morphology and encapsulation efficiency of insulin. The in vitro release of insulin from microspheres was studied under...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2005
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2005.01.016